With the REST study (REgistering Sleep during Trauma treatment) Hein van Marle aims to translate basic findings on the role of sleep in emotional memory to the patient-level in PTSD.
A growing literature highlights the role of sleep in emotional regulation and memory. These findings suggest that sleep is essential in the treatment of post-traumatic stress disorder (PTSD). In this Amsterdam Neuroscience Alliance project, Hein together with Eus van Someren and Miranda Olff is out to identify the role of sleep in ongoing PTSD treatment by assessing the day-to-day interrelatedness between different sleep parameters (like duration of slow wave sleep, sleep spindle count and REM-fragmentation) and treatment outcome during a 5-day high intensity treatment. Sleep will be registered every night using a single-lead ambulatory EEG-device.
Apart from guiding the development of new, possibly sleep-related interventions in PTSD, these findings will additionally form the basis for a large collaborative, multidisciplinary grant proposal with Amsterdam Neuroscience partners studying new sleep-related interventions in trauma- and stress-related disorders.
H.J.F. (Hein) van Marle, MD PhD