Central to the ΤΟ_ΑΙΤΙΟΝ’s approach are unique longitudinal cohorts (with >15 years of follow-up) and biobanks, containing clinical, demographic, biochemical and biological information, as well as extensive genomic, epigenomic, transcriptomic, proteomic, lipidomic, metabolomics and microbiomic data.
These will be explored with systems biology approaches and artificial intelligence methodologies to uncover novel factors and pathways linked to immunemetabolic dysregulation and development of co/multimorbid disease and shed light into the pathophysiological mechanisms involved.
Causality will be evaluated in experimental animal models and cell systems where the role of myeloid progenitor cell reprogramming in this process will also be determined. Through the analysis of TO_AITION’s cohorts, the trajectory of multimorbid disease development will further be characterized, new biomarkers identified, and a new diagnostic test, in the form of a lab-on-chip, and a risk prediction tool will be developed.
OBJ 1 | To build maps of immune cell-specific genomic, epigenomic, transcriptomic and proteomic characteristics from healthy individuals and patients.
OBJ 2 | To characterize CVD-depression multimorbidity phenotypes, imune-metabolic profiles and pathobiological states linked to clinical phenotypes through systems biology and artificial intelligence approaches
OBJ 3 | To identify common mechanisms, risk and susceptibility factors driving co/multimorbidities through hypothesis and data-driven high dimensional approaches, and causal inference studies
OBJ 4 | Evaluation of causality of novel factors and pathways identified in purpose-built human cellbased and animal models
OBJ 5 | To identify novel biomarkers for the diagnosis, prognosis and monitoring of CVD-depression multimorbidities
OBJ 6 | To develop a novel lab-on-chip test for the diagnosis, prognosis and monitoring of CVDdepression multimorbidities in patients
OBJ 7 | To develop a new multiscale risk model to identify high versus low risk states to assist the diagnosis and management of CVD-depression multimorbidities
OBJ 8 | To plan medical professionals and patients-focused awareness programs and educational activities for CVD-depression multimorbidities
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 848146.