My research is focused on the complex links between major depression and age-related biology. Using a wide range of neuroscientific methods, I aim to: a) identify determinants of age-related biology and mental ill-health, b) study their longitudinal dynamics, and c) evaluate prognostic potential and reversibility following treatment. With a background in neuroscience and specific training in biomarkers of mental ill-health, I completed my PhD in Psychiatry awarded with a cum laude distinction. My thesis revealed that adults with depression appear biologically older than non-depressed peers, and I have extended this work to early-intervention in young people aged 15-25 years (NWO Rubicon). The next step is to aggregate high-quality diverse datasets from around the world to assess the consistency of findings across cohorts with the aim to promote the clinical application of age-related biomarkers in major depression (NWO Veni).