In an effort to understand how the regional involvement of dopamine signaling promotes healthy and pathological behavioural functions, in this study we employ behavioural paradigms that disentangle two of dopamine’s main functions: reward prediction and movement. PhD student Lizz Fellinger applies fiber photometry and optogenetics in freely behaving animals to measure and manipulate pre- and postsynaptic dopamine signaling in several striatal regions and/or related to a specific basal ganglia output pathway (“D1” or “D2”)

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