The Academic Collaborative Center Bipolar disorders includes the academic outpatient clinics of GGZ inGeest for bipolar disorders that are based in Amsterdam (De Nieuwe Valerius) and Hoofddorp (Spaarnepoort). Together they treat about 700 patients with bipolar spectrum disorder. We have a long tradition in diagnosing and treating this complex mood disorder and its often comorbid conditions, using pharmacotherapy, psychotherapy and specialized psychosocial interventions. Acute manic and depressive episodes both have major challenges, as has long-term prophylactic treatment. In addition, every year we do about forty second opinions for complex diagnostics or treatment resistance, which are referred from all over the country. Given this combination of high-quality specialised patient care, clinical research, and teaching, in 2022 we were recognised as a TOPGGz center for bipolar disorders (TOPGGz). We have a close collaboration with the TOPGGz Centres of Altrecht (Utrecht) and Dimence (Deventer).