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Ingo Willuhn, i.willuhn@nin.knaw.nl

Neural correlates of compulsivity in a genetic model for OCD and the effects of DBS in corticostriatal circuits

Compulsivity is a core symptom of obsessive-compulsive disorder (OCD) and other conditions like addiction. Compulsivity is often associated with altered activity in the corticostriatal circuits. The goal of this PhD research is to contribute to the understanding of the neural basis of compulsivity using a mouse model for OCD. By studying the network and single neuron activity of the corticostriatal circuit during the expression of compulsive behaviour, we aim to detect biomarkers of compulsive behaviour, both spontaneous and behaviourally-induced.

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