Our daily interactions with the world are supported by neural correlates at different levels of complexity. While the activity of individual neurons in specific brain areas can encode discrete features of external stimuli, higher-order cognitive processes—such as action execution or inhibition of action—are better reflected in more complex neural correlates, such as the coordinated activity of neuronal populations across different regions and the networks they form. Using multidimensional analysis of calcium imaging signals and extracellular electrophysiology, Sergio aims to understand how the coordinated activity of cortico-striatal neuronal populations reflects key elements of compulsive behavior in rodent models of compulsivity.
